jQuery is a library, which makes DOM manipulations and event handling easier.
Handsontable is fully compatible with jQuery - the small example below shows that the integration between the two is quick and intuitive.
In order to use Handsontable as a jQuery plugin, you need to do some preparation:
<link rel="stylesheet" media="screen" href="handsontable/dist/handsontable.full.css">
handsontable()plugin constructor on an empty div as in the below code example: